Welcome to our bumper edition dedicated to gut health and the microbiome - a massive, and increasingly mainstream topic, with substantial amounts of new research published daily. This 3rd edition of the NED Journal shines a light on the many and varied ways the microbiome interacts with human health, from different disease states and multiple life stages. It includes sections on the common diagnosis of irritable bowel disease, as well as the challenging autoimmune inflammatory bowel diseases.